Pareto-optimal balancing conflicting objectives in genome subgroup analysis.
AVAtar is a readily usable standalone software for analysis and visualisation of alteration data. AVAtar features interactively customizable alteration plots, extensive data import capabilities and a multi-objective optimization algorithm to find alteration patterns, e.g. gene sets with mutually exclusive alterations or small gene sets with high sample coverage.
The software is available at
Our paper "Awakening the HSC: Dynamic Modeling of HSC Maintenance Unravels Regulation of the TP53 Pathway and Quiescence" has been published in Frontiers in Physiology.
Our review article "Concepts in Boolean Network Modeling - What Do They All Mean?" has been published in Computational and Structural Biotechnology Journal.