Medical Systems Biology

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Einführung in die Bioinformatik(Informatik/ Mathematische Biometrie)

Dozent: Prof. Dr. Hans A. Kestler
  Prof. Dr. Enno Ohlebusch
  Dr. Karlheinz Holzmann
  mit M. Sc. Lea Siegle








Vorlesungsbeginn ist am 16.10.2019

Die Besichtigung der Core Facility Genomics findet am 22.01.2020 statt. Treffpunkt ist um 8:30 in O27, 123.


*NEU* Die Klausureinsicht für die Nachklausur findet am 26.06.2020 von 10-11 Uhr in O28/2001 statt. Bitte beachten Sie, dass Sie den Raum nur einzeln betreten dürfen und auf den Laufwegen der Uni sowie während der Einsicht immer einen Mund-Nasen-Schutz tragen und 1.5m Abstand zu anderen Perspnen halten müssen.



Mittwochs 08:30 - 10:00 Uhr, O27, 123


Freitags 14:00 - 16:00 Uhr, O27, 121, alle zwei Wochen

Die Übung, die am 31.01.2020 stattfinden sollte, wird auf den 07.02.2020 verlegt.




Biologische Grundlagen (I/II)

Biologische Grundlagen (II/II)

Datenbanken und Alignments


Next Generation Sequencing





Übungsblatt 1

Übungsblatt 2

Übungsblatt 3

Übungsblatt 4

Übungsblatt 5

Übungsblatt 6

Übungsblatt 7








Erster Termin: 25.02.2020, 10:00-12:00 Uhr, O27/H20

Zweiter Termin: 19.06.2020, 08:00-11:00 Uhr, O27/H20

Latest News


Our paper "A systems biology approach to define mechanisms, phenotypes, and drivers in PanNETs with a personalized perspective" has been published in npj systems biology and applications.


"Supporting SURgery with GEriatric Co-Management and AI (SURGE-Ahead): A study protocol for the development of a digital geriatrician" has been published in PLoS One.


"Self-Assessment of Having COVID-19 With the Corona Check Mhealth App" has been published in IEEE Journal of Biomedical and Health Informatics.

Our first quantum computing paper "Leveraging quantum computing for dynamic analyses of logical networks in systems biology" has been published in Patterns.


Our paper "Unsupervised domain adaptation for the detection of cardiomegaly in cross-domain chest X-ray images" has been published in Frontiers in Artificial Intelligence.


  1. "The HLA ligandome of oropharyngeal squamous cell carcinomas reveals shared tumour-exclusive peptides for semi-personalised vaccination" has been published online first in the British Journal of Cancer.


"Vaccine Side Effects in Health Care Workers after Vaccination against SARS-CoV-2: Data from TüSeRe:exact Study" has been published in Viruses-Basel.


"PREDICT-juvenile-stroke: PRospective evaluation of a prediction score determining individual clinical outcome three months after ischemic stroke in young adults – a study protocol" has been published in BMC Neurology.


Our paper "Federated Electronic Data Capture (fEDC): Architecture and Prototype" has been accepted for publiaction in the Journal of Biomedical Informatics.


Our paper "Efficient cross-valdation traversals in feature subset selection" has been published in Scientific Reports.


Our paper "CANTATA - prediction of missing links in Boolean networks using genetic programming" has been published in Bioinformatics.


Our paper "Interaction Empowerment in Mobile Health: Concepts, Challenges, and Perspectives" has been published in the Journal of Medical Internet Research mhealth and uhealth.


Our paper "Identification of dynamic driver sets controlling phenotypical landscapes" has been published in the Computational and Structural Biotechnology Journal.