Medical Systems Biology

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Bioinformatics and Systems Biology (MolMed)

Coordinator: Prof. Dr. H. A. Kestler

Code: MOME.Ma1002

 


Announcement:

Start of lectures:

Tuesday, 22.10.2019 (14:00 - 16:00)

 

Room changes:

Thursday, 24.10.2019 (16:00 - 18:00): O29, 3004

Tuesday, 31.10.2019 (14:00 - 16:00): O29, 3005/3006

Thursday, 28.11.2019 (14:00 - 16:00): O23, 2609/10

 

Lectures:

Tuesday (14:00 - 16:00): seminar room surgical clinic 3.391 

Thursday (14:00 - 16:00): O23, 2611 

 

Exercises:

Thursday (16:00 - 18:00): O29, 3005/3006

 

Exam:

The post-exam review will take place on 11.02.2020 (12:00-13:00) in room O29/2003.


Friday, 07.02.2020 (10:00 - 12:00): Hörsaal Chirurgie (Lecture Hall Surgery)

 

Slides:

Introduction

Signalling

Epigenetics

Programming with R and Bioconductor

Multivariate Statistics

Data Mining

High throughput technologies

Mass spectrometry and Proteomics - basics

Bioinformatics in MS based qualitative and quantitative proteomics

Mass spectrometry and Proteomics - NewDrugs

Sequence Analysis

Sequence Analysis - Manuscript

Simulation and modeling

Mathematical analysis of cell function

Boolean Networks

Qualitative Models Extensions

Quantitive Models

Exercise sheets:

Exercise sheet 1

Exercise sheet 2

Exercise sheet 3

Exercise sheet 4

Exercise sheet 5

Exercise sheet 6

Exercise sheet 7

Exercise sheet 8

Additional material:

Time table

R Cheat sheet

Exercise sheet 1: data_Sha_64.txt

Exercise sheet 2: multivariate_statistics.RData

Exercise sheet 2: knn.Data.RData

Exercise sheet 4: Exercises-2019.mgf

Job Openings

Wissenschaftlicher Mitarbeiter (m/w/d) 

 

Latest News

 

  1. Our paper "Prediction of resistance to bevacizumab plus FOLFOX in metastatic colorectal cancer-Results of the prospective multicenter PERMAD trial" has been published in PLoS One.

     

  2. "Introducing a machine learning algorithm for delirium prediction—the Supporting SURgery with GEriatric Co-Management and AI project (SURGE-Ahead)has been published in Age and Ageing.

Our paper "Segmentation-based cardiomegaly detection based on semi-supervised estimation of cardiothoracic ratio" has been published in Scientific Reports.

 

"Prospective study validating a multidimensional treatment decision score predicting the 24-month outcome in untreated patients with clinically isolated syndrome and early relapsing–remitting multiple sclerosis, the ProVal-MS study" has been published in Neurological Research and Practice.

 

Our paper "GatekeepR: an R shiny application for the identification of nodes with high dynamic impact in boolean networks" has been published online first in Bioinformatics.

 

Our paper "The Necessity of Interoperability to Uncover the Full Potential of Digital Health Devices" has been published in JMIR Medical Informatics.

 

"Multicentric pilot study to standardize clinical whole exome sequencing (WES) for cancer patients" has been published in npj Precision Oncology.

 

Our paper "AMBAR-interactive alteration annotations for molecular tumor boards" has been published in Computer Methods and Programs in Biomedicine.

 

"A protocol for the use of cloud-based quantum computers for logical network analysis of biological systems" has been published in STAR Protocols.

 

Our paper "A systems biology approach to define mechanisms, phenotypes, and drivers in PanNETs with a personalized perspective" has been published in npj systems biology and applications.

 

"Supporting SURgery with GEriatric Co-Management and AI (SURGE-Ahead): A study protocol for the development of a digital geriatrician" has been published in PLoS One.

 

"Self-Assessment of Having COVID-19 With the Corona Check Mhealth App" has been published in IEEE Journal of Biomedical and Health Informatics.


Our first quantum computing paper "Leveraging quantum computing for dynamic analyses of logical networks in systems biology" has been published in Patterns.