Medical Systems Biology

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Einführung in die Bioinformatik(Informatik/ Mathematische Biometrie)

Dozent: Prof. Dr. Hans A. Kestler
  Prof. Dr. Enno Ohlebusch
  Dr. Karlheinz Holzmann
  mit M. Sc. Robin Szekely
Code

 

CS6012.000

 

 

 

 


Aktuelles

Vorlesungsbeginn ist am 17.10.2018

Die erste Übung (Einführung in R und Ausgabe des ersten Übungsblatts) findet am 26.10.2018 statt

Die Besichtigung der Core Facility Genomics findet am 09.01.2019 statt. Treffpunkt ist um 8:30 in O27, 123.

Die Vorlesung am 30.01.2019 entfällt krankheitsbedingt. Die Übung am 01.02.2019 findet aber regulär statt.

Die Klausureinsicht zur ersten Klausur findet am 15.03.2019, 15:00-16:00 in O27/5116 (Besprechungsraum) statt.

Die Klausureinsicht zur Nachklausur findet am 03.05.2019, 09:30-10:30 in O27/548 statt.


Vorlesung

Mittwochs 08:30 - 10:00 Uhr, O27, 123


Übungen

Freitags 14:00 - 16:00 Uhr, O27, 121, ab 26.10.2018 alle zwei Wochen

 

Vorlesungsunterlagen

Biologische Grundlagen

Molekulare Werkzeuge

Datenbanken und Alignments

Microarrays

Next Generation Sequencing

Statistik

Klassifikation

Clustering

 

Übungsblätter

Übungsblatt 1

Übungsblatt 2

Übungsblatt 3

Übungsblatt 4

Übungsblatt 5

Übungsblatt 6

Übungsblatt 7

Sonstiges

Einführung in R

PAM250.RData

Animation: k-Means

Animation: Perzeptron

normal_vs_prostate_tumor.RData

mapping_table.RData

test_data.RData

multTest.RData

Klausur

Erster Termin: 26.02.2019, 10:00-11:30 Uhr, O27/H20

Zweiter Termin: 09.04.2019, 10:00-11:30 Uhr, N25/H8

 

Job Openings

Wissenschaftlicher Mitarbeiter (m/w/d) 

 

Latest News

 

Our paper "Identification of ordinal relations and alternative suborders within high-dimensional molecular data" has been published in Frontiers in Bioinformatics.

 

Our paper "Dealing with Class Overlap Through Cluster-BasedSample Weighting" has been published in Computers.

 

Our paper "A novel quantum algorithm for efficient attractor search in gene regulatory networks" has been published in Patterns.

 

Our paper "CLL to Richter syndrome: Integrating network strategies with experiments elucidating disease drivers and personalized therapies" has been published in Science Advances.

 

"Deep Learning Predicts Postoperative Mobility, Activities of Daily Living, and Discharge Destination in Older Adults from Sensor Data" has been published in Sensors.

 

Our paper "Robust signalling entropy estimation for biological process characterization" has been published in Briefings in Bioinformatics.

 

"Proposal for Using AI to Assess Clinical Data Integrity and Generate Metadata: Algorithm Development and Validation" has been published in JMIR Medical Informatics.

 

Our paper "Sparse keypoint segmentation of lung fissures: efficient geometric deep learning for abstracting volumetric images" has been published in the International Journal of Computer Assisted Radiology and Surgery. Please find electronical supplementary material here.


  1. "Hydra has mammal-like mutation rates facilitating fast adaptation despite its nonaging phenotype" has been published in Genome Research.


Our paper "Boolean network modeling and its integration with experimental read-outs: An interdiscipliary presentation using a leukemia model" has been published online first in Pathologie.

  1.  

    "Combined analysis of a serum mRNA/miRNA marker signature and CA 19-9 for timely and accurate diagnosis of recurrence after resection of pancreatic ductal adenocarcinoma: A prospective multicenter cohort study" has been published online first in the United European Gastroenterology Journal.

     

    "Identifications of Similarity Metrics for Patients With Cancer: Protocol for a Scoping Review" has been published in JMIR Research Protocols.

     

    "Recent Trends and Future Challenges in Learning from Data" has been published with Springer.

     

    Our paper "Permutation-invariant linear classifiers" has been published in Machine Learning.

     

    Our paper "Prediction of resistance to bevacizumab plus FOLFOX in metastatic colorectal cancer-Results of the prospective multicenter PERMAD trial" has been published in PLoS One.

     

  2. "Introducing a machine learning algorithm for delirium prediction—the Supporting SURgery with GEriatric Co-Management and AI project (SURGE-Ahead)has been published in Age and Ageing.

Our paper "Segmentation-based cardiomegaly detection based on semi-supervised estimation of cardiothoracic ratio" has been published in Scientific Reports.

 

"Prospective study validating a multidimensional treatment decision score predicting the 24-month outcome in untreated patients with clinically isolated syndrome and early relapsing–remitting multiple sclerosis, the ProVal-MS study" has been published in Neurological Research and Practice.

 

Our paper "GatekeepR: an R shiny application for the identification of nodes with high dynamic impact in boolean networks" has been published online first in Bioinformatics.

 

Our paper "The Necessity of Interoperability to Uncover the Full Potential of Digital Health Devices" has been published in JMIR Medical Informatics.

 

"Multicentric pilot study to standardize clinical whole exome sequencing (WES) for cancer patients" has been published in npj Precision Oncology.

 

Our paper "AMBAR-interactive alteration annotations for molecular tumor boards" has been published in Computer Methods and Programs in Biomedicine.

 

"A protocol for the use of cloud-based quantum computers for logical network analysis of biological systems" has been published in STAR Protocols.

 

Our first quantum computing paper "Leveraging quantum computing for dynamic analyses of logical networks in systems biology" has been published in Patterns.