Medical Systems Biology

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Joint research projects

  • BIU-Project (Boehringer Ingelheim Ulm University BioCenter): 
    • Project N7: "Diagnostic role and predictive value of cyclic nucleotides in neuropsychiatric co-morbidities of Alzheimer’s disease"
  • Symbol-HF (BMBF, eMed): "Systems Medicine to dissect the Biology of Heart Failure"
  • SFB 1074(DFG): "Experimental Models and Clinical Translation in Leukemia"
    • Project Z1: "Parallel Algorithms for Robust Clustering, Classification, and Visualization"
  • CAM-PaC(European Comission, FP7): "Integrative Analysis of Gene Functions in Cellular and Animal Models of Pancreatic Cancer"
    • WP10: "Data Integration and Modeling"
  • SyStaR(BMBF, GerontoSys 2): "Molecular Systems Biology of Impaired Stem Cell Function and Regeneration during Aging"
    • Research Group Kestler
    • Research Group Senior PI (provisional)
    • Research Group Junior PI (provisional)
  • Genomics Core Facility, Ulm University
    • HAK is coordinator of bioinformatics
  • International Graduate School in Molecular Medicine, Ulm University
    • HAK is member of the PhD Committee
 

Research Training Projects

  

  • Research Training Group 2254: "Heterogeneity and Evolution in Solid Tumours" (HEIST):
    • Project A2: "Systems biology of tumour evolution: Estimating partial orders from omics data"
    • HAK is co-director of HEIST

 

Finished joint research projects


  • NGFN-Plus (BMBF): "Translational Genome Research Network in Pancreatic Cancer"
    • Project TP11B: "Molecular Diagnosis of Pancreatic Cancer"
  • SFB 518 (DFG): "Inflammation, Regeneration and Transformation in the Pancreas"
    • Project C05: "Robust Algorithms for Clustering and Classification of Pancreatic Cells and Tissues"

Latest News

 

Our first quantum computing paper "Leveraging quantum computing for dynamic analyses of logical networks in systems biology" has been published in Patterns.

 

Our paper "Unsupervised domain adaptation for the detection of cardiomegaly in cross-domain chest X-ray images" has been published in Frontiers in Artificial Intelligence.

 

  1. "The HLA ligandome of oropharyngeal squamous cell carcinomas reveals shared tumour-exclusive peptides for semi-personalised vaccination" has been published online first in the British Journal of Cancer.

 

"Vaccine Side Effects in Health Care Workers after Vaccination against SARS-CoV-2: Data from TüSeRe:exact Study" has been published in Viruses-Basel.

 

"PREDICT-juvenile-stroke: PRospective evaluation of a prediction score determining individual clinical outcome three months after ischemic stroke in young adults – a study protocol" has been published in BMC Neurology.

 

Our paper "Federated Electronic Data Capture (fEDC): Architecture and Prototype" has been accepted for publiaction in the Journal of Biomedical Informatics.

 

Our paper "Efficient cross-valdation traversals in feature subset selection" has been published in Scientific Reports.

 

Our paper "CANTATA - prediction of missing links in Boolean networks using genetic programming" has been published in Bioinformatics.

 

Our paper "Interaction Empowerment in Mobile Health: Concepts, Challenges, and Perspectives" has been published in the Journal of Medical Internet Research mhealth and uhealth.

 

Our paper "Identification of dynamic driver sets controlling phenotypical landscapes" has been published in the Computational and Structural Biotechnology Journal.


Congratulations to Dr. Silke Werle for winning the 1st Prize with her pitch at the 1. Science Day held by ProTrainU. 

 

Our paper "Reconstructing Boolean network ensembles from single-cell data for unraveling dynamics in the aging of human hematopoietic stem cells" has been published in the Computational and Structural Biotechnology Journal.

 

The position paper "Is there a role for statistics in artificial intelligence" has been published online first in Advances in Data Analysis and Classification.