Medical Systems Biology

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Einführung in die Bioinformatik(Informatik/ Mathematische Biometrie)

Dozent: Prof. Dr. Hans A. Kestler
  Prof. Dr. Enno Ohlebusch
  Dr. Karlheinz Holzmann
  mit M. Sc. Robin Szekely








Vorlesungsbeginn ist am 17.10.2018

Die erste Übung (Einführung in R und Ausgabe des ersten Übungsblatts) findet am 26.10.2018 statt

Die Besichtigung der Core Facility Genomics findet am 09.01.2019 statt. Treffpunkt ist um 8:30 in O27, 123.

Die Vorlesung am 30.01.2019 entfällt krankheitsbedingt. Die Übung am 01.02.2019 findet aber regulär statt.

Die Klausureinsicht zur ersten Klausur findet am 15.03.2019, 15:00-16:00 in O27/5116 (Besprechungsraum) statt.

Die Klausureinsicht zur Nachklausur findet am 03.05.2019, 09:30-10:30 in O27/548 statt.


Mittwochs 08:30 - 10:00 Uhr, O27, 123


Freitags 14:00 - 16:00 Uhr, O27, 121, ab 26.10.2018 alle zwei Wochen



Biologische Grundlagen

Molekulare Werkzeuge

Datenbanken und Alignments


Next Generation Sequencing






Übungsblatt 1

Übungsblatt 2

Übungsblatt 3

Übungsblatt 4

Übungsblatt 5

Übungsblatt 6

Übungsblatt 7


Einführung in R


Animation: k-Means

Animation: Perzeptron






Erster Termin: 26.02.2019, 10:00-11:30 Uhr, O27/H20

Zweiter Termin: 09.04.2019, 10:00-11:30 Uhr, N25/H8


Latest News


Our first quantum computing paper "Leveraging quantum computing for dynamic analyses of logical networks in systems biology" has been published in Patterns.


Our paper "Unsupervised domain adaptation for the detection of cardiomegaly in cross-domain chest X-ray images" has been published in Frontiers in Artificial Intelligence.


  1. "The HLA ligandome of oropharyngeal squamous cell carcinomas reveals shared tumour-exclusive peptides for semi-personalised vaccination" has been published online first in the British Journal of Cancer.


"Vaccine Side Effects in Health Care Workers after Vaccination against SARS-CoV-2: Data from TüSeRe:exact Study" has been published in Viruses-Basel.


"PREDICT-juvenile-stroke: PRospective evaluation of a prediction score determining individual clinical outcome three months after ischemic stroke in young adults – a study protocol" has been published in BMC Neurology.


Our paper "Federated Electronic Data Capture (fEDC): Architecture and Prototype" has been accepted for publiaction in the Journal of Biomedical Informatics.


Our paper "Efficient cross-valdation traversals in feature subset selection" has been published in Scientific Reports.


Our paper "CANTATA - prediction of missing links in Boolean networks using genetic programming" has been published in Bioinformatics.


Our paper "Interaction Empowerment in Mobile Health: Concepts, Challenges, and Perspectives" has been published in the Journal of Medical Internet Research mhealth and uhealth.


Our paper "Identification of dynamic driver sets controlling phenotypical landscapes" has been published in the Computational and Structural Biotechnology Journal.

Congratulations to Dr. Silke Werle for winning the 1st Prize with her pitch at the 1. Science Day held by ProTrainU. 


Our paper "Reconstructing Boolean network ensembles from single-cell data for unraveling dynamics in the aging of human hematopoietic stem cells" has been published in the Computational and Structural Biotechnology Journal.


The position paper "Is there a role for statistics in artificial intelligence" has been published online first in Advances in Data Analysis and Classification.