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Medical Systems Biology

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Research

The rapid development of molecular biology has given rise to an increasing demand in computational and mathematical approaches to analyze and understand the resulting data. In particular, advanced methods from Bioinformatics are required to extract and investigate the essential information from high-throughput experiments, such as microarrays or Next Generation Sequencing. The emerging field of Systems Biology provides formal approaches to modeling and simulating regulatory processes in biological systems.

Research fields

Cluster analysis Molecular networks Classification Visualization & Functional annotation

The research of our group is at the interface of computer science, statistics and life sciences and covers the following main aspects:

Latest News

Our paper "Awakening the HSC: Dynamic Modeling of HSC Maintenance Unravels Regulation of the TP53 Pathway and Quiescence" has been published in Frontiers in Physiology.

 

Our review article "Concepts in Boolean Network Modeling - What Do They All Mean?" has been published in Computational and Structural Biotechnology Journal.