Medical Systems Biology

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Systems Biology

Interactions of genes and gene products as well as cross-talks between individual pathways make up complex networks that preclude an intuitive understanding. Along with the increase in knowledge on genetic interactions, mathematical modeling and simulation have become indispensible tools for the analysis of regulatory networks.

WNT signaling pathway

Modeling approaches vary in the degree of abstraction, which influences the level of detail, but also comprehensibility and the amount of information required to specify the model parameters. Our research covers the highly abstract Boolean models as well as comprehensive models based on differential equations.

Latest News

 

The position paper "Is there a role for statistics in artificial intelligence" has been published online first in Advances in Data Analysis and Classification.

 

Our paper "Corona Health - A Study- and Sensor-Based Mobile App Platform Exploring Aspects of the COVID-19 Pandemic" has been published in the International Journal of Environmental Research and Public Health.

 

Our paper "Patient empowerment during the COVID-19 pandemic: Ensuring safe and fast communication of test results" has been published in the Journal of Medical Internet Research.

 

Our paper "Perspective on mHealth Concepts to Ensure Users’ Empowerment–From Adverse Event Tracking for COVID-19 Vaccinations to Oncological Treatment" has been published in IEEE Access.

 

Our paper "Capturing dynamic relevance in Boolean networks using graph theoretical measures" has been published online first in Bioinformatics.

 

Our report protocol "Digitalization of adverse event management in oncology to improve treatment outcome—A prospective study protocol" has been published in PLoS One.

 

We are happy we could contribute to Beutel et al (2021) "A prospective Feasibility Trial to Challenge Patient-Derived Pancreatic Cancer Organoids in Predicting Treatment Response" published in MDPI Cancers.