Medical Systems Biology

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Visual inspection is often a first step in identifying key features of data. The high dimensionality of biological data sets prohibits an intuitive understanding and requires advanced visualization techniques. Our group develops visualization tools to support researchers in inspecting different types of biological data, e.g. for automatic tracking of cells in live cell imaging, displaying locations of SNPs on a caryogram, linking human cytomegalovirus drug resistance mutations to phenotypes, or visualizing the stability of selected gene subsets. Our heavily used VennMaster software provides algorithms to display area-proportional Venn diagrams of set intersections.

An area-proportional Venn diagram of GO categories


Selected publications


L. Lausser, C. Müssel, M. Maucher, and H. A. Kestler. Measuring and visualizing the stability of biomarker selection techniques. Computational Statistics, 28(1):51–65, 2013.

J. Huth, M. Buchholz, J. M. Kraus, K. Molhave, C. Gradinaru, G. von Wichert, T. M. Gress, H. Neumann, and H. A. Kestler. TimeLapseAnalyzer: multi-target analysis for live-cell imaging and time-lapse microscopy. Comput Methods Programs Biomed, 104(2):227–34, 2011.

M. Chevillotte, J. von Einem, B. M. Meier, F. M. Lin, H. A. Kestler, and T. Mertens. A new tool linking human cytomegalovirus drug resistance mutations to resistance phenotypes. Antiviral Res., 85:318–327, 2010.

H. A. Kestler, A. Müller, J. M. Kraus, M. Buchholz, T. M. Gress, H. Liu, D. W. Kane, B. R. Zeeberg, and J. N. Weinstein. VennMaster: Area-proportional Euler diagrams for functional GO analysis of microarrays. BMC Bioinformatics, 9(1):67, 2008.

A. Müller, K.-H. Holzmann, and H. A. Kestler. Visualization of genomic aberrations using Affymetrix SNP arrays. Bioinformatics, 23(4):496–7, 2007.

H. A. Kestler, A. Müller, M. Buchholz, T. Gress, and G. Palm. A perceptually optimized scheme for vsiualizing gene expression ratios with confidence values. In E. André, L. Dybkjær, W. Minker, H. Neumann, and M. Weber, editors, Perception and Interactive Technologies (PIT 06), volume LNAI 4021, pages 73–84. Springer-Verlag, Heidelberg, 2006.

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Wissenschaftlicher Mitarbeiter (m/w/d) 


Latest News


Our paper "A systems biology approach to define mechanisms, phenotypes, and drivers in PanNETs with a personalized perspective" has been published in npj systems biology and applications.


"Supporting SURgery with GEriatric Co-Management and AI (SURGE-Ahead): A study protocol for the development of a digital geriatrician" has been published in PLoS One.


"Self-Assessment of Having COVID-19 With the Corona Check Mhealth App" has been published in IEEE Journal of Biomedical and Health Informatics.

Our first quantum computing paper "Leveraging quantum computing for dynamic analyses of logical networks in systems biology" has been published in Patterns.


Our paper "Unsupervised domain adaptation for the detection of cardiomegaly in cross-domain chest X-ray images" has been published in Frontiers in Artificial Intelligence.


  1. "The HLA ligandome of oropharyngeal squamous cell carcinomas reveals shared tumour-exclusive peptides for semi-personalised vaccination" has been published online first in the British Journal of Cancer.


"Vaccine Side Effects in Health Care Workers after Vaccination against SARS-CoV-2: Data from TüSeRe:exact Study" has been published in Viruses-Basel.


"PREDICT-juvenile-stroke: PRospective evaluation of a prediction score determining individual clinical outcome three months after ischemic stroke in young adults – a study protocol" has been published in BMC Neurology.


Our paper "Federated Electronic Data Capture (fEDC): Architecture and Prototype" has been accepted for publiaction in the Journal of Biomedical Informatics.


Our paper "Efficient cross-valdation traversals in feature subset selection" has been published in Scientific Reports.


Our paper "CANTATA - prediction of missing links in Boolean networks using genetic programming" has been published in Bioinformatics.


Our paper "Interaction Empowerment in Mobile Health: Concepts, Challenges, and Perspectives" has been published in the Journal of Medical Internet Research mhealth and uhealth.


Our paper "Identification of dynamic driver sets controlling phenotypical landscapes" has been published in the Computational and Structural Biotechnology Journal.