Medical Systems Biology

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Proseminar Bioinformatik und Systembiologie


Prof. Dr. Hans A. Kestler, Dr. Ludwig Lausser 

Termine und Ankündigung

  • Vorbesprechung: 25.04.2018, um 16:00 Uhr, Raum: O27 / 121


Inhalt und Themen

Die Studierenden sollen anhand von Beispielen aus der Bioinformatik und Systembiologie das selbstständige Arbeiten in einem wissenschaftlichen Themengebiet erlernen. Sie sollen die grundlegenden Zusammenhänge und Herausforderungen des Themengebietes erfassen und in Form von wissenschaftlichen Vorträgen und Ausarbeitungen wiedergeben können. 



High Throughput Technologien (Big Data)

  • Microarrays
  • Next Generation Sequencing (NGS)

 Data Science für hochdimensionale Daten

  • Datenintegration und -analyse
  • Identifikation von Biomarkern
  • Visualisierung


Modellierung biologischer Netzwerke

  • Bool'sche Netzwerke
  • Differentialgleichungssysteme (ODE)
  • Cloud-/ Gridcomputing


Besichtigung der Genomics-Facility (optional)

Im Rahmen des Proseminars wird eine Besichtung der Genomics-Facility der Universität Ulm angeboten. Für diese ist eine Anmeldung erforderlich.



Zur Erlangung des Proseminarscheins wird von den Studierenden folgendes erwartet:

1. Schriftliche Ausarbeitung

2. Wissenschaftlicher Vortrag

3. Die Anwesenheit bei allen vorgegebenen Terminen.

4. Die Einhaltung aller vorgegebenen Fristen.

Job Openings

Wissenschaftlicher Mitarbeiter (m/w/d) 


Latest News


  1. Our paper "Permutation-invariant linear classifiers" has been published in Machine Learning.


    Our paper "Prediction of resistance to bevacizumab plus FOLFOX in metastatic colorectal cancer-Results of the prospective multicenter PERMAD trial" has been published in PLoS One.


  2. "Introducing a machine learning algorithm for delirium prediction—the Supporting SURgery with GEriatric Co-Management and AI project (SURGE-Ahead)has been published in Age and Ageing.

Our paper "Segmentation-based cardiomegaly detection based on semi-supervised estimation of cardiothoracic ratio" has been published in Scientific Reports.


"Prospective study validating a multidimensional treatment decision score predicting the 24-month outcome in untreated patients with clinically isolated syndrome and early relapsing–remitting multiple sclerosis, the ProVal-MS study" has been published in Neurological Research and Practice.


Our paper "GatekeepR: an R shiny application for the identification of nodes with high dynamic impact in boolean networks" has been published online first in Bioinformatics.


Our paper "The Necessity of Interoperability to Uncover the Full Potential of Digital Health Devices" has been published in JMIR Medical Informatics.


"Multicentric pilot study to standardize clinical whole exome sequencing (WES) for cancer patients" has been published in npj Precision Oncology.


Our paper "AMBAR-interactive alteration annotations for molecular tumor boards" has been published in Computer Methods and Programs in Biomedicine.


"A protocol for the use of cloud-based quantum computers for logical network analysis of biological systems" has been published in STAR Protocols.


Our paper "A systems biology approach to define mechanisms, phenotypes, and drivers in PanNETs with a personalized perspective" has been published in npj systems biology and applications.


"Supporting SURgery with GEriatric Co-Management and AI (SURGE-Ahead): A study protocol for the development of a digital geriatrician" has been published in PLoS One.


"Self-Assessment of Having COVID-19 With the Corona Check Mhealth App" has been published in IEEE Journal of Biomedical and Health Informatics.

Our first quantum computing paper "Leveraging quantum computing for dynamic analyses of logical networks in systems biology" has been published in Patterns.