Medical Systems Biology

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Classification

An automated categorization of probes can provide assistance to medical investigators in many diagnostic settings. The models obtained from the training procedure of a classifier can provide insights into the structure of the data, in particular into the properties that distinguish the categories.

A combination of two single-threshold classifiers

A focus of our research lies on ensembles of single-threshold classifiers, which allow for an easy interpretation of the models. We also investigate methods to assess and compare classifier models theoretically and empirically, and to optimize classifier parameters.

 

Selected publications

 

L. Lausser, C. Müssel, A. Melkozerov, and H. A. Kestler. Identifying predictive hubs to condense the training set of k-nearest neighbour classifiers. Computational Statistics, 29(1-2):81-95, 2014.

L. Lausser, F. Schmid, M. Schmid, and H. A. Kestler. Unlabeling data can improve classification accuracy. Pattern Recognition Letters, 37:15-23, 2014.

T. M. Gress, H. A. Kestler, L. Lausser, L. Fiedler, B. Sipos, C. W. Michalski, J. Werner, N. Giese, A. Scarpa, and M. Buchholz. Differentiation of multiple types of pancreatico-biliary tumors by molecular analysis of clinical specimens. J Mol Med (Berl), 2012.

M. Watabe-Rudolph, Z. Song, L. Lausser, C. Schnack, Y. Begus-Nahrmann, M. Scheithauer, G. Rettinger, M. Otto, H. Tumani, D. R. Thal, J. Attems, K. A. Jellinger, H. A. Kestler, C. A. F. von Arnim, and K. L. Rudolph. Chitinase enzyme activity in CSF is a powerful biomarker of alzheimer disease. Neurology, 78(8):569–577, 2012.

C. Müssel, L. Lausser, M. Maucher, and H. A. Kestler. Multi-Objective parameter selection for classifiers. Journal of Statistical Software, 46(5):1–27, 2012.

L.-H. Meyer, S. M. Eckhoff, M. Queudeville, J. M. Kraus, M. Giordan, J. Stursberg, A. Zangrando, E. Vendramini, A. Moericke, M. Zimmermann, A. Schrauder, G. Lahr, K. Holzmann, M. Schrappe, G. Basso, K. Stahnke, H. A. Kestler, G. te Kronnie, and K.-M. Debatin. Early Relapse in Pediatric ALL is identified by Time To Leukemia in NOD/SCID mice and is characterized by a gene signature involving survival pathways. Cancer Cell, 19(2):206–217, 2011.

M. Buchholz, H. A. Kestler, A. Bauer, W. Böck, B. Rau, G. Leder, W. Kratzer, M. Bommer, A. Scarpa, M. K. Schilling, G. Adler, J. D. Hoheisel, and T. M. Gress. Specialized DNA arrays for the differentiation of pancreatic tumors. Clin Cancer Res, 11(22):8048–54, 2005.

Job Openings

Wissenschaftlicher Mitarbeiter (m/w/d) 

 

Latest News

 

  1. Our paper "Prediction of resistance to bevacizumab plus FOLFOX in metastatic colorectal cancer-Results of the prospective multicenter PERMAD trial" has been published in PLoS One.

     

  2. "Introducing a machine learning algorithm for delirium prediction—the Supporting SURgery with GEriatric Co-Management and AI project (SURGE-Ahead)has been published in Age and Ageing.

Our paper "Segmentation-based cardiomegaly detection based on semi-supervised estimation of cardiothoracic ratio" has been published in Scientific Reports.

 

"Prospective study validating a multidimensional treatment decision score predicting the 24-month outcome in untreated patients with clinically isolated syndrome and early relapsing–remitting multiple sclerosis, the ProVal-MS study" has been published in Neurological Research and Practice.

 

Our paper "GatekeepR: an R shiny application for the identification of nodes with high dynamic impact in boolean networks" has been published online first in Bioinformatics.

 

Our paper "The Necessity of Interoperability to Uncover the Full Potential of Digital Health Devices" has been published in JMIR Medical Informatics.

 

"Multicentric pilot study to standardize clinical whole exome sequencing (WES) for cancer patients" has been published in npj Precision Oncology.

 

Our paper "AMBAR-interactive alteration annotations for molecular tumor boards" has been published in Computer Methods and Programs in Biomedicine.

 

"A protocol for the use of cloud-based quantum computers for logical network analysis of biological systems" has been published in STAR Protocols.

 

Our paper "A systems biology approach to define mechanisms, phenotypes, and drivers in PanNETs with a personalized perspective" has been published in npj systems biology and applications.

 

"Supporting SURgery with GEriatric Co-Management and AI (SURGE-Ahead): A study protocol for the development of a digital geriatrician" has been published in PLoS One.

 

"Self-Assessment of Having COVID-19 With the Corona Check Mhealth App" has been published in IEEE Journal of Biomedical and Health Informatics.


Our first quantum computing paper "Leveraging quantum computing for dynamic analyses of logical networks in systems biology" has been published in Patterns.