Medical Systems Biology

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ODE modeling

Quantitative models have a long tradition in developmental biology. The most common approach specifies the systems as ordinary differential equations (ODE). The equations describe the concentrations of reactants over time.

 

An ODE model for irradiation-induced differentiation across subpopulations of haematopoietic stem cells 

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Our research particularly focuses on the Wnt signaling pathway, and on models for stem cell renewal and ageing.

 

Selected publications

 

K. Hein, G. Mittler, W. Cizelsky, M. Kühl, F. Ferrante, R. Liefke, I. M. Berger, S. Just, J. E. Sträng, H. A Kestler, F. Oswald, T. Borggrefe. Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response. Science signaling, 8(369):ra30, 2015.

J. Wang, Q. Sun, Y. Morita, H. Jiang, A. Groß, A. Lechel, K. Hildner, L. M. Guachalla, A. Gompf, D. Hartmann, A. Schambach, T. Wuestefeld, D. Dauch, H. Schrezenmeier, W. Hofmann, H. Nakauchi, Z. Ju, H. A. Kestler, L. Zender, and K. L. Rudolph. A differentiation checkpoint limits hematopoietic stem cell Self-Renewal in response to DNA damage. Cell, 148(5):1001–1014, 2012.

H. A. Kestler and M. Kühl. Generating a Wnt switch: it's all about the right dosage. J Cell Biol, 193(3):431–3, 2011.

H. A. Kestler, C. Wawra, B. Kracher, and M. Kühl. Network modelling of signal transduction: establishing the global view. BioEssays, 30(11-12):1110–1125, 2008.

C. Wawra, M. Kühl, and H. A. Kestler. Extended analyses of the Wnt/beta-catenin pathway: Robustness and oscillatory behaviour. FEBS Lett, 581/21:4043–4048, 2007.

Job Openings

Wissenschaftlicher Mitarbeiter (m/w/d) 

 

Latest News

 

Our paper "GatekeepR: an R shiny application for the identification of nodes with high dynamic impact in boolean networks" has been published online first in Bioinformatics.

 

Our paper "The Necessity of Interoperability to Uncover the Full Potential of Digital Health Devices" has been published in JMIR Medical Informatics.

 

"Multicentric pilot study to standardize clinical whole exome sequencing (WES) for cancer patients" has been published in npj Precision Oncology.

 

Our paper "AMBAR-interactive alteration annotations for molecular tumor boards" has been published in Computer Methods and Programs in Biomedicine.

 

"A protocol for the use of cloud-based quantum computers for logical network analysis of biological systems" has been published in STAR Protocols.

 

Our paper "A systems biology approach to define mechanisms, phenotypes, and drivers in PanNETs with a personalized perspective" has been published in npj systems biology and applications.

 

"Supporting SURgery with GEriatric Co-Management and AI (SURGE-Ahead): A study protocol for the development of a digital geriatrician" has been published in PLoS One.

 

"Self-Assessment of Having COVID-19 With the Corona Check Mhealth App" has been published in IEEE Journal of Biomedical and Health Informatics.


Our first quantum computing paper "Leveraging quantum computing for dynamic analyses of logical networks in systems biology" has been published in Patterns.