Interactions of genes and gene products as well as cross-talks between individual pathways make up complex networks that preclude an intuitive understanding. Along with the increase in knowledge on genetic interactions, mathematical modeling and simulation have become indispensible tools for the analysis of regulatory networks.
Modeling approaches vary in the degree of abstraction, which influences the level of detail, but also comprehensibility and the amount of information required to specify the model parameters. Our research covers the highly abstract Boolean models as well as comprehensive models based on differential equations.
Our paper "A Boolean Network of the Crosstalk Between IGF and Wnt Signaling in Aging Satellite Cells" has been published in Plos One.
Our paper "Long-lived rodents reveal signatures of positive selection in genes associated with lifespan" has been published in Plos Genetics.