Interactions of genes and gene products as well as cross-talks between individual pathways make up complex networks that preclude an intuitive understanding. Along with the increase in knowledge on genetic interactions, mathematical modeling and simulation have become indispensible tools for the analysis of regulatory networks.
Modeling approaches vary in the degree of abstraction, which influences the level of detail, but also comprehensibility and the amount of information required to specify the model parameters. Our research covers the highly abstract Boolean models as well as comprehensive models based on differential equations.
Our paper "Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma" has been accepted for publishing in Scientific Reports.
Our paper "Central Nervous System Involvement in Acute Lymphoblastic Leukemia Is Mediated by Vascular Endothelial Growth Factor" has been accepted for publishing in Blood.